艾美捷科技代理Gene Tools品牌

Gene Tools是一家生产和销售Morpholino Anti-sense oligos（反义寡核苷酸)的公司，其产品专门用于基因调控的科学研究和药物开发。Gene Tools公司由多位资深科学家组成，为全球客户提供免费的技术咨询和Morpholino 序列设计服务。 Morpholino作为基因调控研究的最佳工具，已被广泛用于：阻断靶mRNA 翻译 (下调基因）；诱导RNA选择性剪接 (下调或上调基因）；阻断 miRNA；阻断病毒 RNA；阻断 non-coding RNA。

▍Morpholino介绍

Morpholino属于第三代反义寡核苷酸，主要通过阻断蛋白质翻译过程而达到抑制目标基因功能的作用，目前已经广泛用于发育生物学和细胞学实验中，并取得了非常好的实验效果。

Morpholino以吗啉环类似物为基本骨架，这种独特的结构特性使得Morpholino 具有以下几个特点：

● 与其他类型的反义寡核苷酸相比，Morpholino 能更好地抵抗核酸酶的作用；

● Morpholino 与靶序列结合后通过空间位阻效应发挥作用， 不激活RNaseH，不引起目标基因mRNA 的降解 ；

● 针对翻译起始位点区设计的Morpholino 用于抑制蛋白质的翻译，针对 pre-mRNA 剪切位点区设计的Morpholino 可影响mRNA 剪切，得到不 同的转录本，可以方便地用于目标基因结构域的突变研究；

● 与靶序列结合能力强，可以渗入mRNA 的二级结构， 并且特异性好。

配合Morpholino 的使用，Gene Tools公司开发了相应的递送系统，可以安全、高效地将Morpholino 输送至胞内，因此，Morpholino 也可以用于遗传学研究和新药靶标的发现以及验证。此外，Morpholino 可以标上荧光基团、亲和标签以及活性反应基团，以供不同的研究需要。

▍Gene Tools公司产品介绍

● Custom Morpholino：可以根据目标基因序列定制设计并合成Morpholino，用于体外细胞实验或某些直接显微注射的模型（如斑马鱼、非洲爪蟾胚胎）。

● Vivo-Morpholino：适用于活体动物模型（小鼠，大鼠，狗，灵长类等），细胞培养，器官培养等。通过特殊的末端修饰，提高了其穿透细胞膜进入组织细胞的能力，使得在成年动物（主要是小鼠、大鼠）中进行系统性基因功能研究成为可能。

● Prepared Control Oligos：根据特定需求合成细胞穿透肽偶联的 Morpholino。适用于活体动物模型（小鼠，大鼠，狗，灵长类等），细胞培养，器官培养等。

● Endo-Porter：为了解决Morpholino在体外培养细胞中摄取效率低的问题，Gene Tools 开发了 Endo-Porter 这种特殊的转染试剂。它通过温和的内吞体逃逸机制帮助Morpholino进入细胞质。

艾美捷科技特约代理Biogems产品。

BioGems意为生物钻石，其产品涵盖多种荧光标记的流式抗体、具有生物活性的功能性抗体，以及流式细胞术辅助试剂，如溶血剂和破膜剂等。BioGems产品全部在美国生产，目前已拥有超过500种流式试剂和600余种重组蛋白产品。

Through the establishment of joint collaborations with reputable manufacturers of top-quality life-science research products such as PeproTech Inc., BioGems has positioned itself to become a highly competitive source for a wide-range of recombinant protein and flow-cytometry reagents. Currently, our catalog contains more than 600 recombinant proteins and over 500 flow cytometry reagents. To keep up with the rapidly advancing research fronts, BioGems continuously adds new products to its catalog. All of our products are subjected to a thorough and rigorous quality and performance testing to ensure that each and every product meets the highest established standards. Providing our customers with the highest-quality products at affordable prices is our goal. We are confident that the unique business arrangements of BioGems together with our highly skilled and experienced personnel will enable us to achieve this goal.

主要产品分类：

（1）Flow Cytometry

Conjugated Antibodies

SAFIRE Functional Antibodies

Isotype Controls

Custom and Bulk Reagents

Purified Antibodies

Buffers and Solutions

（2）Recombinant Proteins

Growth Factors & Cytokines

Animal-Free Cytokines

Chemokines

Neurotrophins

Other Proteins

Anti Cytokine & Chemokine Antibodies

（3）Small Molecules

Receptor Antagonist and Inhibitors

Receptor Agonists and Activators

（4）Pre-Coated Elisa Kits

Human

Mouse

Rat

Novus Biologicals，抗体一站式服务专家。作为世界上最大的抗体生产商，Novus Biologicals 携近16万种抗体席卷而来，完美解决您的需求。

The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products for the lifesciences. Novus Biologicals is also organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research.

All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving both niche and emerging markets, Novus Biologicals has built solid partnerships with our customers. Contact us for more information.

Novus的主要产品包括：

（1）Antibodies

Primary Antibodies

Conjugated Antibodies

Sample Size Antibodies

Antibody Sampler Packs

Antibody Pairs

Secondary Antibodies

Isotype Control Antibodies

（2）Proteins and Peptides

Peptides & Proteins

Blocking Peptides

Biologically Active Proteins

（3）Lysates and Cell Lines

Lysates

Reporter Cell Lines

Stem Cell Lines

（4）Kits

Antibody Labeling Kits

ChIP Kits

ELISA Kits

Flow Cytometry Kits

Exosome Kits

（5）Activators and Inhibitors

Inhibitors

Activators

（6）Support Products

IHC Tissue Slides

IHC Microarrays

Western Blot Membranes

RNAi

All Support Products

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艾美捷科技有限公司

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